16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networ...
16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Reciprocal copy number variations (CNVs) of 16p11.2 are associated with a wide spectrum of neuropsychiatric and neurodevelopmental disorders. Here, we use human induced pluripotent stem cells (iPSCs)-derived dopaminergic (DA) neurons carrying CNVs of 16p11.2 duplication (16pdup) and 16p11.2 deletion (16pdel), engineered using CRISPR-Cas9. We show t...
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16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro
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TN_cdi_doaj_primary_oai_doaj_org_article_b6ffb9fd39d845a3b76fce24f582a800
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b6ffb9fd39d845a3b76fce24f582a800
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-23113-z
