A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substa...
A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration
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Singapore: Springer Nature Singapore
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Language
English
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Singapore: Springer Nature Singapore
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Current SARS-CoV-2 Omicron subvariants impose a heavy burden on global health systems by evading immunity from most developed neutralizing antibodies and vaccines. Here, we identified a nanobody (aSA3) that strongly cross-reacts with the receptor binding domain (RBD) of both SARS-CoV-1 and wild-type (WT) SARS-CoV-2. The dimeric construct of aSA3 (a...
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Full title
A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration
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TN_cdi_doaj_primary_oai_doaj_org_article_b7230cc378744ffabb71cda1a27ced13
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b7230cc378744ffabb71cda1a27ced13
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ISSN
2056-5968
E-ISSN
2056-5968
DOI
10.1038/s41421-022-00497-w
