Loss of the zinc receptor ZnR/GPR39 in mice enhances anxiety-related behavior and motor deficits, an...
Loss of the zinc receptor ZnR/GPR39 in mice enhances anxiety-related behavior and motor deficits, and modulates KCC2 expression in the amygdala
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Mood disorders, particularly depression and anxiety, are associated with zinc dyshomeostasis and aberrant GABAergic signaling. Activation of ZnR/GPR39 by synaptic zinc in the hippocampus triggers phosphorylation of extracellular regulated kinase (ERK1/2), which regulates the K
/Cl
cotransporter (KCC2) and thereby GABAergic inhibitory neurotra...
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Full title
Loss of the zinc receptor ZnR/GPR39 in mice enhances anxiety-related behavior and motor deficits, and modulates KCC2 expression in the amygdala
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TN_cdi_doaj_primary_oai_doaj_org_article_b73ca095e18e44249b2f0c65c17e45ba
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b73ca095e18e44249b2f0c65c17e45ba
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ISSN
1744-9081
E-ISSN
1744-9081
DOI
10.1186/s12993-024-00254-x
