Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating s...
Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit
About this item
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Author / Creator
Rozman Grinberg, Inna , Lundin, Daniel , Hasan, Mahmudul , Crona, Mikael , Jonna, Venkateswara Rao , Loderer, Christoph , Sahlin, Margareta , Markova, Natalia , Borovok, Ilya , Berggren, Gustav , Hofer, Anders , Logan, Derek T , Sjöberg, Britt-Marie , Naturvetenskapliga fakulteten , Department of Chemistry , Biochemistry and Structural Biology , Lund University , Biokemi och Strukturbiologi , Center for Molecular Protein Science , Kemiska institutionen , Faculty of Science , Lunds universitet and Centrum för Molekylär Proteinvetenskap
Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
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Publisher
England: eLife Science Publications, Ltd
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Scope and Contents
Contents
Ribonucleotide reductases (RNRs) are key enzymes in DNA metabolism, with allosteric mechanisms controlling substrate specificity and overall activity. In RNRs, the activity master-switch, the ATP-cone, has been found exclusively in the catalytic subunit. In two class I RNR subclasses whose catalytic subunit lacks the ATP-cone, we discovered ATP-con...
Alternative Titles
Full title
Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit
Authors, Artists and Contributors
Author / Creator
Lundin, Daniel
Hasan, Mahmudul
Crona, Mikael
Jonna, Venkateswara Rao
Loderer, Christoph
Sahlin, Margareta
Markova, Natalia
Borovok, Ilya
Berggren, Gustav
Hofer, Anders
Logan, Derek T
Sjöberg, Britt-Marie
Naturvetenskapliga fakulteten
Department of Chemistry
Biochemistry and Structural Biology
Lund University
Biokemi och Strukturbiologi
Center for Molecular Protein Science
Kemiska institutionen
Faculty of Science
Lunds universitet
Centrum för Molekylär Proteinvetenskap
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b748293d383c40c1839ef9c37f256aa8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b748293d383c40c1839ef9c37f256aa8
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.31529
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