Metformin attenuates triglyceride accumulation in HepG2 cells through decreasing stearyl-coenzyme A...
Metformin attenuates triglyceride accumulation in HepG2 cells through decreasing stearyl-coenzyme A desaturase 1 expression
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Author / Creator
Zhu, Xiaopeng , Yan, Hongmei , Xia, Mingfeng , Chang, Xinxia , Xu, Xi , Wang, Liu , Sun, Xiaoyang , Lu, Yan , Bian, Hua , Li, Xiaoying and Gao, Xin
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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Contents
The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased worldwide. Metformin decreases triglyceride (TG) accumulation in hepatocytes in vivo and in vitro. Stearyl-coenzyme A desaturase 1 (SCD1) knockout mice also show decreased liver TG accumulation; however, whether SCD1 plays a role in the effect of metformin on TG accumulation i...
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Full title
Metformin attenuates triglyceride accumulation in HepG2 cells through decreasing stearyl-coenzyme A desaturase 1 expression
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TN_cdi_doaj_primary_oai_doaj_org_article_b79a4015e7924252b82b42b437fd8c0e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b79a4015e7924252b82b42b437fd8c0e
Other Identifiers
ISSN
1476-511X
E-ISSN
1476-511X
DOI
10.1186/s12944-018-0762-0
