Imputation-free reconstructions of three-dimensional chromosome architectures in human diploid singl...
Imputation-free reconstructions of three-dimensional chromosome architectures in human diploid single-cells using allele-specified contacts
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Single-cell Hi-C analysis of diploid human cells is difficult because of the lack of dense chromosome contact information and the presence of homologous chromosomes with very similar nucleotide sequences. Thus here, we propose a new algorithm to reconstruct the three-dimensional (3D) chromosomal architectures from the Hi-C dataset of single diploid...
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Imputation-free reconstructions of three-dimensional chromosome architectures in human diploid single-cells using allele-specified contacts
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TN_cdi_doaj_primary_oai_doaj_org_article_b82eac6ee87c4897abc317420adc7c99
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b82eac6ee87c4897abc317420adc7c99
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-022-15038-4
