p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-ren...
p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs
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Author / Creator
Choi, Hye Yeon , Siddique, Hifzur R. , Zheng, Mengmei , Kou, Yi , Yeh, Da-Wei , Machida, Tatsuya , Chen, Chia-Lin , Uthaya Kumar, Dinesh Babu , Punj, Vasu , Winer, Peleg , Pita, Alejandro , Sher, Linda , Tahara, Stanley M. , Ray, Ratna B. , Liang, Chengyu , Chen, Lin , Tsukamoto, Hidekazu and Machida, Keigo
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Tumor-initiating stem-like cells (TICs) are defective in maintaining asymmetric cell division and responsible for tumor recurrence. Cell-fate-determinant molecule NUMB-interacting protein (TBC1D15) is overexpressed and contributes to p53 degradation in TICs. Here we identify TBC1D15-mediated oncogenic mechanisms and tested the tumorigenic roles of...
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Full title
p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs
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TN_cdi_doaj_primary_oai_doaj_org_article_b860fba9de8448de8c15f0811ec7cae9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b860fba9de8448de8c15f0811ec7cae9
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16616-8
