STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melan...
STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice
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England: BMJ Publishing Group Ltd
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Language
English
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England: BMJ Publishing Group Ltd
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BackgroundMyeloid-derived suppressor cells (MDSCs) represent a negative prognostic factor in malignant melanoma. These cells are generated under chronic inflammatory conditions typical of cancer. The transcription factor signal transducer and activator of transcription 3 (STAT3) orchestrates MDSC accumulation and acquisition of immunosuppressive pr...
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STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice
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TN_cdi_doaj_primary_oai_doaj_org_article_b8976245c18444668e5ab0d45bbf8c81
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b8976245c18444668e5ab0d45bbf8c81
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ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2021-004384
