Identification of novel off targets of baricitinib and tofacitinib by machine learning with a focus...
Identification of novel off targets of baricitinib and tofacitinib by machine learning with a focus on thrombosis and viral infection
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
As there are no clear on-target mechanisms that explain the increased risk for thrombosis and viral infection or reactivation associated with JAK inhibitors, the observed elevated risk may be a result of an off-target effect. Computational approaches combined with in vitro studies can be used to predict and validate the potential for an approved dr...
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Identification of novel off targets of baricitinib and tofacitinib by machine learning with a focus on thrombosis and viral infection
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TN_cdi_doaj_primary_oai_doaj_org_article_b90a0be877b546d1a81f84dd7bbe2044
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b90a0be877b546d1a81f84dd7bbe2044
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-022-11879-1
