A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance
A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance
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Author / Creator
Hammerling, Babette C. , Najor, Rita H. , Cortez, Melissa Q. , Shires, Sarah E. , Leon, Leonardo J. , Gonzalez, Eileen R. , Boassa, Daniela , Phan, Sébastien , Thor, Andrea , Jimenez, Rebecca E. , Li, Hong , Kitsis, Richard N. , Dorn, Gerald W. , Sadoshima, Junichi , Ellisman, Mark H. and Gustafsson, Åsa B.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal. The currently recognized mechanism for disposal of mitochondria is autophagy, where damaged organelles are marked for disposal via ubiquitylation by Parkin. Here we report a novel pathway for mitochondrial elimination, in which these organelles undergo Parkin...
Alternative Titles
Full title
A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance
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TN_cdi_doaj_primary_oai_doaj_org_article_b90a7538f1694e4281da0c789cbd7c2c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b90a7538f1694e4281da0c789cbd7c2c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms14050
