A simplified function-first method for the discovery and optimization of bispecific immune engaging...
A simplified function-first method for the discovery and optimization of bispecific immune engaging antibodies
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Publisher
Public Library of Science (PLoS)
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Language
English
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Public Library of Science (PLoS)
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Contents
Bi-specific T-cell engager antibodies (BiTEs) are synthetic fusion molecules that combine multiple antibody-binding domains to induce active contact between T-cells and antigen expressing cells in the body. Blinatumomab, a CD19-CD3 BiTE is now a widely used therapy for relapsed B-cell malignancies, and similar BiTE therapeutics have shown promise f...
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Full title
A simplified function-first method for the discovery and optimization of bispecific immune engaging antibodies
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TN_cdi_doaj_primary_oai_doaj_org_article_b963816902bb40d5ba44061d2e1b1911
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b963816902bb40d5ba44061d2e1b1911
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E-ISSN
1932-6203
