Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Re...
Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Anxiety and depression affect 35–50% of patients with Parkinson’s disease (PD), often precede the onset of motor symptoms, and have a negative impact on their quality of life. Dysfunction of the serotonergic (5-HT) system, which regulates mood and emotional pathways, occurs during the premotor phase of PD and contributes to a variety of non-motor s...
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Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy
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TN_cdi_doaj_primary_oai_doaj_org_article_b96ac20039604ef38d882ae21ef22355
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b96ac20039604ef38d882ae21ef22355
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ISSN
2158-3188
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2158-3188
DOI
10.1038/s41398-022-01842-z
