Phase 1, dose-escalation study of guadecitabine (SGI-110) in combination with pembrolizumab in patie...
Phase 1, dose-escalation study of guadecitabine (SGI-110) in combination with pembrolizumab in patients with solid tumors
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Author / Creator
Papadatos-Pastos, Dionysis , Yuan, Wei , Pal, Abhijit , Crespo, Mateus , Ferreira, Ana , Gurel, Bora , Prout, Toby , Ameratunga, Malaka , Chénard-Poirier, Maxime , Curcean, Andra , Bertan, Claudia , Baker, Chloe , Miranda, Susana , Masrour, Nahal , Chen, Wentin , Pereira, Rita , Figueiredo, Ines , Morilla, Ricardo , Jenkins, Ben , Zachariou, Anna , Riisnaes, Ruth , Parmar, Mona , Turner, Alison , Carreira, Suzanne , Yap, Christina , Brown, Robert , Tunariu, Nina , Banerji, Udai , Lopez, Juanita , de Bono, Johann and Minchom, Anna
Publisher
London: BMJ Publishing Group Ltd
Journal title
Language
English
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Publication information
Publisher
London: BMJ Publishing Group Ltd
Subjects
More information
Scope and Contents
Contents
BackgroundData suggest that immunomodulation induced by DNA hypomethylating agents can sensitize tumors to immune checkpoint inhibitors. We conducted a phase 1 dose-escalation trial (NCT02998567) of guadecitabine and pembrolizumab in patients with advanced solid tumors. We hypothesized that guadecitabine will overcome pembrolizumab resistance.Metho...
Alternative Titles
Full title
Phase 1, dose-escalation study of guadecitabine (SGI-110) in combination with pembrolizumab in patients with solid tumors
Authors, Artists and Contributors
Author / Creator
Yuan, Wei
Pal, Abhijit
Crespo, Mateus
Ferreira, Ana
Gurel, Bora
Prout, Toby
Ameratunga, Malaka
Chénard-Poirier, Maxime
Curcean, Andra
Bertan, Claudia
Baker, Chloe
Miranda, Susana
Masrour, Nahal
Chen, Wentin
Pereira, Rita
Figueiredo, Ines
Morilla, Ricardo
Jenkins, Ben
Zachariou, Anna
Riisnaes, Ruth
Parmar, Mona
Turner, Alison
Carreira, Suzanne
Yap, Christina
Brown, Robert
Tunariu, Nina
Banerji, Udai
Lopez, Juanita
de Bono, Johann
Minchom, Anna
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b9a84246b2264ed1b2c2acbbf2f19d79
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b9a84246b2264ed1b2c2acbbf2f19d79
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2022-004495
