TET2 deficiency increases the competitive advantage of hematopoietic stem and progenitor cells throu...
TET2 deficiency increases the competitive advantage of hematopoietic stem and progenitor cells through upregulation of thrombopoietin receptor signaling
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Ten-Eleven Translocation-2 (
TET2
) mutations drive the expansion of mutant hematopoietic stem cells (HSCs) in clonal hematopoiesis (CH). However, the precise mechanisms by which
TET2
mutations confer a competitive advantage to HSCs remain unclear. Here, through an epigenetic drug screen, we discover that inhibition of disruptor of telo...
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Full title
TET2 deficiency increases the competitive advantage of hematopoietic stem and progenitor cells through upregulation of thrombopoietin receptor signaling
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TN_cdi_doaj_primary_oai_doaj_org_article_b9c348b62d1642198fd157ce6e38d998
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b9c348b62d1642198fd157ce6e38d998
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-57614-y
