Role of HDAC9-FoxO1 Axis in the Transcriptional Program Associated with Hepatic Gluconeogenesis
Role of HDAC9-FoxO1 Axis in the Transcriptional Program Associated with Hepatic Gluconeogenesis
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Chen, Jizheng , Zhang, Zhilei , Wang, Ning , Guo, Min , Chi, Xiumei , Pan, Yu , Jiang, Jing , Niu, Junqi , Ksimu, Sulaiman , Li, John Zhong , Chen, Xinwen and Wang, Qian
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Histone deacetylase 9 (HDAC9) regulates hepatic gluconeogenesis by deacetylating Forkhead box O 1 (FoxO1). HDAC9 upregulation is involved in hepatitis C virus (HCV)-associated exaggerated gluconeogenesis. Herein, we found in addition to FoxO1, HDAC9 also regulates other gluconeogenic transcription factors, including peroxisomeproliferator-activated...
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Full title
Role of HDAC9-FoxO1 Axis in the Transcriptional Program Associated with Hepatic Gluconeogenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_ba549a1520d1468591e57045ecc18cc3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ba549a1520d1468591e57045ecc18cc3
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-06328-3
