PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectivel...
PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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T cell acute lymphoblastic leukemia (T-ALL) is a high-risk subtype that comprises 10-15% of childhood and 20-25% of adult ALL cases. Over 70% of T-ALL patients harbor activating mutations in the NOTCH1 signaling pathway and are predicted to be sensitive to gamma-secretase inhibitors. We have recently demonstrated that selective inhibition of PSEN1-...
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Full title
PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia
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TN_cdi_doaj_primary_oai_doaj_org_article_bb40113fbbf041209361b8411e7b5c92
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bb40113fbbf041209361b8411e7b5c92
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ISSN
1756-8722
E-ISSN
1756-8722
DOI
10.1186/s13045-021-01114-1
