Exploration of the structural requirements of Aurora Kinase B inhibitors by a combined QSAR, modelli...
Exploration of the structural requirements of Aurora Kinase B inhibitors by a combined QSAR, modelling and molecular simulation approach
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Aurora kinase B plays an important role in the cell cycle to orchestrate the mitotic process. The amplification and overexpression of this kinase have been implicated in several human malignancies. Therefore, Aurora kinase B is a potential drug target for anticancer therapies. Here, we combine atom-based 3D-QSAR analysis and pharmacophore model gen...
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Exploration of the structural requirements of Aurora Kinase B inhibitors by a combined QSAR, modelling and molecular simulation approach
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TN_cdi_doaj_primary_oai_doaj_org_article_bb75eda4ab704f4381e3015bca49cdde
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bb75eda4ab704f4381e3015bca49cdde
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-97368-3
