Nitric oxide protects the heart from ischemia-induced apoptosis and mitochondrial damage via protein...
Nitric oxide protects the heart from ischemia-induced apoptosis and mitochondrial damage via protein kinase G mediated blockage of permeability transition and cytochrome c release
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England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Heart ischemia can rapidly induce apoptosis and mitochondrial dysfunction via mitochondrial permeability transition-induced cytochrome c release. We tested whether nitric oxide (NO) can block this damage in isolated rat heart, and, if so, by what mechanisms.
Hearts were perfused with 50 microM DETA/NO (NO donor), then subjected to 30 min stop-fl...
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Full title
Nitric oxide protects the heart from ischemia-induced apoptosis and mitochondrial damage via protein kinase G mediated blockage of permeability transition and cytochrome c release
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TN_cdi_doaj_primary_oai_doaj_org_article_bbdf767496694929b1aac6b6475af63e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bbdf767496694929b1aac6b6475af63e
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ISSN
1423-0127,1021-7770
E-ISSN
1423-0127
DOI
10.1186/1423-0127-16-70
