ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
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Author / Creator
Seo, Ji Hae , Park, Ji-Hyeon , Lee, Eun Ji , Vo, Tam Thuy Lu , Choi, Hoon , Kim, Jun Yong , Jang, Jae Kyung , Wee, Hee-Jun , Lee, Hye Shin , Jang, Se Hwan , Park, Zee Yong , Jeong, Jaeho , Lee, Kong-Joo , Seok, Seung-Hyeon , Park, Jin Young , Lee, Bong Jin , Lee, Mi-Ni , Oh, Goo Taeg and Kim, Kyu-Won
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Heat shock protein (Hsp)70 is a molecular chaperone that maintains protein homoeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. However, the mechanisms by which Hsp70 balances these opposing functions under stress conditions remain unknown. Here, we demonstrate that Hsp70 preferentially facilitates...
Alternative Titles
Full title
ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_bbe3b18cb62b4560996ac9f25bb15fdb
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bbe3b18cb62b4560996ac9f25bb15fdb
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12882
