Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary...
Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Inhibitors of poly-ADP-ribose polymerase 1 (PARPi) are highly effective in killing cells deficient in homologous recombination (HR); thus, PARPi have been clinically utilized to successfully treat BRCA2-mutant tumors. However, positive response to PARPi is not universal, even among patients with HR-deficiency. Here, we present the results of genome...
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Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens
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TN_cdi_doaj_primary_oai_doaj_org_article_bbee1b004cdc4bdebae2ddc9b6d5a3f3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bbee1b004cdc4bdebae2ddc9b6d5a3f3
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19961-w
