Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders
Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Heart failure, the leading cause of mortality and morbidity in the developed world, is characterized by cardiac ryanodine receptor 2 channels that are hyperphosphorylated, oxidized, and depleted of the stabilizing subunit calstabin-2. This results in a diastolic sarcoplasmic reticulum Ca
2+
leak that impairs cardiac contractility and triggers...
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Full title
Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders
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TN_cdi_doaj_primary_oai_doaj_org_article_bc2929b1c98e4fc79d74e5bb8c72f229
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bc2929b1c98e4fc79d74e5bb8c72f229
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-51791-y
