A physiologically‐based pharmacokinetic/pharmacodynamic modeling approach for drug–drug‐gene interac...
A physiologically‐based pharmacokinetic/pharmacodynamic modeling approach for drug–drug‐gene interaction evaluation of S‐warfarin with fluconazole
About this item
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Author / Creator
Geng, Kuo , Shen, Chaozhuang , Wang, Xiaohu , Wang, Xingwen , Shao, Wenxin , Wang, Wenhui , Chen, Tao , Sun, Hua and Xie, Haitang
Publisher
United States: John Wiley & Sons, Inc
Journal title
Language
English
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Publication information
Publisher
United States: John Wiley & Sons, Inc
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Scope and Contents
Contents
Warfarin is a widely used anticoagulant, and its S‐enantiomer has higher potency compared to the R‐enantiomer. S‐warfarin is mainly metabolized by cytochrome P450 (CYP) 2C9, and its pharmacological target is vitamin K epoxide reductase complex subunit 1 (VKORC1). Both CYP2C9 and VKORC1 have genetic polymorphisms, leading to large variations in the...
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Full title
A physiologically‐based pharmacokinetic/pharmacodynamic modeling approach for drug–drug‐gene interaction evaluation of S‐warfarin with fluconazole
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_bc477cb1364e4e1cb94d302dd4ad816c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bc477cb1364e4e1cb94d302dd4ad816c
Other Identifiers
ISSN
2163-8306
E-ISSN
2163-8306
DOI
10.1002/psp4.13123
