MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen recept...
MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets
About this item
Full title
Author / Creator
Qiu, Xintao , Boufaied, Nadia , Hallal, Tarek , Feit, Avery , de Polo, Anna , Luoma, Adrienne M. , Alahmadi, Walaa , Larocque, Janie , Zadra, Giorgia , Xie, Yingtian , Gu, Shengqing , Tang, Qin , Zhang, Yi , Syamala, Sudeepa , Seo, Ji-Heui , Bell, Connor , O’Connor, Edward , Liu, Yang , Schaeffer, Edward M. , Jeffrey Karnes, R. , Weinmann, Sheila , Davicioni, Elai , Morrissey, Colm , Cejas, Paloma , Ellis, Leigh , Loda, Massimo , Wucherpfennig, Kai W. , Pomerantz, Mark M. , Spratt, Daniel E. , Corey, Eva , Freedman, Matthew L. , Shirley Liu, X. , Brown, Myles , Long, Henry W. and Labbé, David P.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
c-MYC (MYC) is a major driver of prostate cancer tumorigenesis and progression. Although MYC is overexpressed in both early and metastatic disease and associated with poor survival, its impact on prostate transcriptional reprogramming remains elusive. We demonstrate that MYC overexpression significantly diminishes the androgen receptor (AR) transcr...
Alternative Titles
Full title
MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets
Authors, Artists and Contributors
Author / Creator
Boufaied, Nadia
Hallal, Tarek
Feit, Avery
de Polo, Anna
Luoma, Adrienne M.
Alahmadi, Walaa
Larocque, Janie
Zadra, Giorgia
Xie, Yingtian
Gu, Shengqing
Tang, Qin
Zhang, Yi
Syamala, Sudeepa
Seo, Ji-Heui
Bell, Connor
O’Connor, Edward
Liu, Yang
Schaeffer, Edward M.
Jeffrey Karnes, R.
Weinmann, Sheila
Davicioni, Elai
Morrissey, Colm
Cejas, Paloma
Ellis, Leigh
Loda, Massimo
Wucherpfennig, Kai W.
Pomerantz, Mark M.
Spratt, Daniel E.
Corey, Eva
Freedman, Matthew L.
Shirley Liu, X.
Brown, Myles
Long, Henry W.
Labbé, David P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_bc90d144fd374a6387fda7079a332f9f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bc90d144fd374a6387fda7079a332f9f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-30257-z
