Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycosi...
Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycoside target and potential alternative mechanism of action
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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A clinically relevant inhibitor for Heptosyltransferase I (HepI) has been sought after for many years because of its critical role in the biosynthesis of lipopolysaccharides on bacterial cell surfaces. While many labs have discovered or designed novel small molecule inhibitors, these compounds lacked the bioavailability and potency necessary for th...
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Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycoside target and potential alternative mechanism of action
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TN_cdi_doaj_primary_oai_doaj_org_article_bcc4b0c42cce4877be0993ff4f99cb78
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bcc4b0c42cce4877be0993ff4f99cb78
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-022-10776-x
