SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8+ T cells
SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8+ T cells
About this item
Full title
Author / Creator
Wu, Zhongqiu , Huang, Haiyan , Han, Qiaoqiao , Hu, Zhilin , Teng, Xiao-Lu , Ding, Rui , Ye, Youqiong , Yu, Xiaoyan , Zhao, Ren , Wang, Zhengting and Zou, Qiang
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
The functional integrity of CD8+ T cells is tightly coupled to metabolic reprogramming, but how oxidative stress directs CD8+ T cell metabolic fitness in the tumor microenvironment (TME) remains elusive. Here, we report that SUMO-specific protease 7 (SENP7) senses oxidative stress to maintain the CD8+ T cell metabolic state and antitumor functions....
Alternative Titles
Full title
SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8+ T cells
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_bce971c1f1ba4234932e0f5467d2d683
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bce971c1f1ba4234932e0f5467d2d683
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI155224
