Stable expression of HIV-1 MPER extended epitope on the surface of the recombinant probiotic bacteri...
Stable expression of HIV-1 MPER extended epitope on the surface of the recombinant probiotic bacteria Escherichia Coli Nissle 1917 using CRISPR/Cas9
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Mucosal vaccines have the potential to induce protective immune responses at the sites of infection. Applying CRISPR/Cas9 editing, we aimed to develop a probiotic-based vaccine candidate expressing the HIV-1 envelope membrane-proximal external region (MPER) on the surface of E. coli Nissle 1917.
The HIV-1 MPER epitope was successfully introduced...
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Full title
Stable expression of HIV-1 MPER extended epitope on the surface of the recombinant probiotic bacteria Escherichia Coli Nissle 1917 using CRISPR/Cas9
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TN_cdi_doaj_primary_oai_doaj_org_article_bd1491d934aa4aca8c6751eb5384d0a1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bd1491d934aa4aca8c6751eb5384d0a1
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ISSN
1475-2859
E-ISSN
1475-2859
DOI
10.1186/s12934-023-02290-0
