AI-guided pipeline for protein–protein interaction drug discovery identifies a SARS-CoV-2 inhibitor
AI-guided pipeline for protein–protein interaction drug discovery identifies a SARS-CoV-2 inhibitor
About this item
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Author / Creator
Trepte, Philipp , Secker, Christopher , Olivet, Julien , Blavier, Jeremy , Kostova, Simona , Maseko, Sibusiso B , Minia, Igor , Silva Ramos, Eduardo , Cassonnet, Patricia , Golusik, Sabrina , Zenkner, Martina , Beetz, Stephanie , Liebich, Mara J , Scharek, Nadine , Schütz, Anja , Sperling, Marcel , Lisurek, Michael , Wang, Yang , Spirohn, Kerstin , Hao, Tong , Calderwood, Michael A , Hill, David E , Landthaler, Markus , Choi, Soon Gang , Twizere, Jean-Claude , Vidal, Marc and Wanker, Erich E
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Protein–protein interactions (PPIs) offer great opportunities to expand the druggable proteome and therapeutically tackle various diseases, but remain challenging targets for drug discovery. Here, we provide a comprehensive pipeline that combines experimental and computational tools to identify and validate PPI targets and perform early-stage drug...
Alternative Titles
Full title
AI-guided pipeline for protein–protein interaction drug discovery identifies a SARS-CoV-2 inhibitor
Authors, Artists and Contributors
Author / Creator
Secker, Christopher
Olivet, Julien
Blavier, Jeremy
Kostova, Simona
Maseko, Sibusiso B
Minia, Igor
Silva Ramos, Eduardo
Cassonnet, Patricia
Golusik, Sabrina
Zenkner, Martina
Beetz, Stephanie
Liebich, Mara J
Scharek, Nadine
Schütz, Anja
Sperling, Marcel
Lisurek, Michael
Wang, Yang
Spirohn, Kerstin
Hao, Tong
Calderwood, Michael A
Hill, David E
Landthaler, Markus
Choi, Soon Gang
Twizere, Jean-Claude
Vidal, Marc
Wanker, Erich E
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_bd1c8039d8764608818fd46023e76135
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bd1c8039d8764608818fd46023e76135
Other Identifiers
ISSN
1744-4292
E-ISSN
1744-4292
DOI
10.1038/s44320-024-00019-8
