Therapeutic and immunomodulatory potential of pazopanib in malignant phyllodes tumor
Therapeutic and immunomodulatory potential of pazopanib in malignant phyllodes tumor
About this item
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Author / Creator
Ng, Dave Yong Xiang , Li, Zhimei , Lee, Elizabeth , Kok, Jessica Sook Ting , Lee, Jing Yi , Koh, Joanna , Ng, Cedric Chuan-Young , Lim, Abner Herbert , Liu, Wei , Ng, Sheng Rong , Lim, Kah Suan , Huang, Xi Xiao , Hong, Jing Han , Guan, Peiyong , Sim, Yirong , Thike, Aye Aye , Nasir, Nur Diyana Md , Li, Shang , Tan, Puay Hoon , Teh, Bin Tean and Chan, Jason Yongsheng
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Malignant phyllodes tumors (PT) are rare aggressive fibroepithelial neoplasms with high metastatic potential and lack effective therapy. We established a patient-derived xenograft (PDX) and cell line model (designated MPT-S1) of malignant PT which demonstrated clinical response to pazopanib. Whole exome sequencing identified somatic mutations in
Alternative Titles
Full title
Therapeutic and immunomodulatory potential of pazopanib in malignant phyllodes tumor
Authors, Artists and Contributors
Author / Creator
Li, Zhimei
Lee, Elizabeth
Kok, Jessica Sook Ting
Lee, Jing Yi
Koh, Joanna
Ng, Cedric Chuan-Young
Lim, Abner Herbert
Liu, Wei
Ng, Sheng Rong
Lim, Kah Suan
Huang, Xi Xiao
Hong, Jing Han
Guan, Peiyong
Sim, Yirong
Thike, Aye Aye
Nasir, Nur Diyana Md
Li, Shang
Tan, Puay Hoon
Teh, Bin Tean
Chan, Jason Yongsheng
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_bd28bd0bf05246bbaccb1e4e99e36462
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bd28bd0bf05246bbaccb1e4e99e36462
Other Identifiers
ISSN
2374-4677
E-ISSN
2374-4677
DOI
10.1038/s41523-022-00413-1
