Ubiquitin ligase CHFR mediated degradation of VE-cadherin through ubiquitylation disrupts endothelia...
Ubiquitin ligase CHFR mediated degradation of VE-cadherin through ubiquitylation disrupts endothelial adherens junctions
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Vascular endothelial cadherin (VE-cadherin) expressed at endothelial adherens junctions (AJs) is vital for vascular integrity and endothelial homeostasis. Here we identify the requirement of the ubiquitin E3-ligase CHFR as a key mechanism of ubiquitylation-dependent degradation of VE-cadherin. CHFR was essential for disrupting the endothelium throu...
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Full title
Ubiquitin ligase CHFR mediated degradation of VE-cadherin through ubiquitylation disrupts endothelial adherens junctions
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TN_cdi_doaj_primary_oai_doaj_org_article_bd6da7d597ac42feba25fde2e33ebb02
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bd6da7d597ac42feba25fde2e33ebb02
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-42225-2
