An integrative approach to ortholog prediction for disease-focused and other functional studies
An integrative approach to ortholog prediction for disease-focused and other functional studies
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Mapping of orthologous genes among species serves an important role in functional genomics by allowing researchers to develop hypotheses about gene function in one species based on what is known about the functions of orthologs in other species. Several tools for predicting orthologous gene relationships are available. However, these tools can give different results and identification of predicted orthologs is not always straightforward.
We report a simple but effective tool, the Drosophila RNAi Screening Center Integrative Ortholog Prediction Tool (DIOPT; http://www.flyrnai.org/diopt), for rapid identification of orthologs. DIOPT integrates existing approaches, facilitating rapid identification of orthologs among human, mouse, zebrafish, C. elegans, Drosophila, and S. cerevisiae. As compared to individual tools, DIOPT shows increased sensitivity with only a modest decrease in specificity. Moreover, the flexibility built in...
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An integrative approach to ortholog prediction for disease-focused and other functional studies
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TN_cdi_doaj_primary_oai_doaj_org_article_bd6dae26e2e34c4985fbc9a23b24f465
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bd6dae26e2e34c4985fbc9a23b24f465
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ISSN
1471-2105
E-ISSN
1471-2105
DOI
10.1186/1471-2105-12-357
