Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis i...
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma
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Author / Creator
Kuang, Chunmei , Xia, Meijuan , An, Gang , Liu, CuiCui , Hu, Cong , Zhang, Jingyu , Liu, Zhenhao , Meng, Bin , Su, Pei , Xia, Jiliang , Guo, Jiaojiao , Zhu, Yinghong , Liu, Xing , Wu, Xuan , Shen, Yi , Feng, Xiangling , He, Yanjuan , Li, Jian , Qiu, Lugui , Zhou, Jiaxi and Zhou, Wen
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Thrombocytopenia is a major complication in a subset of patients with multiple myeloma (MM). However, little is known about its development and significance during MM. Here, we show thrombocytopenia is linked to poor prognosis in MM. In addition, we identify serine, which is released from MM cells into the bone marrow microenvironment, as a key met...
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Full title
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma
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TN_cdi_doaj_primary_oai_doaj_org_article_bdbd430c87ef4d968ec54131163bb177
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bdbd430c87ef4d968ec54131163bb177
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-37699-z
