Mefloquine-induced conformational shift in Cx36 N-terminal helix leading to channel closure mediated...
Mefloquine-induced conformational shift in Cx36 N-terminal helix leading to channel closure mediated by lipid bilayer
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Connexin 36 (Cx36) forms interneuronal gap junctions, establishing electrical synapses for rapid synaptic transmission. In disease conditions, inhibiting Cx36 gap junction channels (GJCs) is beneficial, as it prevents abnormal synchronous neuronal firing and apoptotic signal propagation, mitigating seizures and progressive cell death. Here, we pres...
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Full title
Mefloquine-induced conformational shift in Cx36 N-terminal helix leading to channel closure mediated by lipid bilayer
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TN_cdi_doaj_primary_oai_doaj_org_article_bdd0f03d3f00427785931b54c7c5ab48
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bdd0f03d3f00427785931b54c7c5ab48
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-53587-6
