Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disea...
Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Cerebrovascular changes occur in Alzheimer’s disease (AD). Using in vivo phage display, we searched for molecular markers of the neurovascular unit, including endothelial cells and astrocytes, in mouse models of AD. We identified a cyclic peptide, CDAGRKQKC (DAG), that accumulates in the hippocampus of hAPP-J20 mice at different ages. Intravenously...
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Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease
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TN_cdi_doaj_primary_oai_doaj_org_article_be95d3c6783044f889e270600ff9b0e4
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_be95d3c6783044f889e270600ff9b0e4
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-01096-0
