Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Stimulation of TNFR1 by TNFα can promote three distinct alternative mechanisms of cell death: necroptosis, RIPK1-independent and -dependent apoptosis. How cells decide which way to die is unclear. Here, we report that TNFα-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating this critical decision. Usin...
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Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
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TN_cdi_doaj_primary_oai_doaj_org_article_bebdf94e5c8e42219dc5cf8b4c649af2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bebdf94e5c8e42219dc5cf8b4c649af2
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00406-w
