Optogenetic actuator – ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics
Optogenetic actuator – ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Combining single‐cell measurements of ERK activity dynamics with perturbations provides insights into the MAPK network topology. We built circuits consisting of an optogenetic actuator to activate MAPK signaling and an ERK biosensor to measure single‐cell ERK dynamics. This allowed us to conduct RNAi screens to investigate the role of 50 MAPK prote...
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Optogenetic actuator – ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics
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TN_cdi_doaj_primary_oai_doaj_org_article_bee64b6e45164b7e9ccb9f4dbd3b946e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bee64b6e45164b7e9ccb9f4dbd3b946e
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ISSN
1744-4292
E-ISSN
1744-4292
DOI
10.15252/msb.202110670
