ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function
ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Proteostasis is a challenge for cellular organisms, as all known protein synthesis machineries are error-prone. Here we show by cell fractionation and microscopy studies that misfolded proteins formed in the endoplasmic reticulum can become associated with and partly transported into mitochondria, resulting in impaired mitochondrial function. Block...
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Full title
ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function
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TN_cdi_doaj_primary_oai_doaj_org_article_bf08851619654161a435709327ef2900
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bf08851619654161a435709327ef2900
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-021-02873-w
