Knockdown of Hyaluronan synthase 2 suppresses liver fibrosis in mice via induction of transcriptomic...
Knockdown of Hyaluronan synthase 2 suppresses liver fibrosis in mice via induction of transcriptomic changes similar to 4MU treatment
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Hepatic fibrosis remains a significant clinical challenge due to ineffective treatments. 4-methylumbelliferone (4MU), a hyaluronic acid (HA) synthesis inhibitor, has proven safe in phase one clinical trials. In this study, we aimed to ameliorate liver fibrosis by inhibiting HA synthesis. We compared two groups of mice with CCl
4
-induced fibr...
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Knockdown of Hyaluronan synthase 2 suppresses liver fibrosis in mice via induction of transcriptomic changes similar to 4MU treatment
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TN_cdi_doaj_primary_oai_doaj_org_article_bf1761999a1a4425962a2dc2b2b8b341
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bf1761999a1a4425962a2dc2b2b8b341
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-024-53089-x
