Novel Sterically Crowded and Conformationally Constrained α-Aminophosphonates with a Near-Neutral pK...
Novel Sterically Crowded and Conformationally Constrained α-Aminophosphonates with a Near-Neutral pKa as Highly Accurate 31P NMR pH Probes. Application to Subtle pH Gradients Determination in Dictyostelium discoideum Cells
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Basel: MDPI AG
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Language
English
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Basel: MDPI AG
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In order to discover new 31P NMR markers for probing subtle pH changes (<0.2 pH unit) in biological environments, fifteen new conformationally constrained or sterically hindered α-aminophosphonates derived from diethyl(2-methylpyrrolidin-2-yl)phosphonate were synthesized and tested for their pH reporting and cytotoxic properties in vitro. All compo...
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Full title
Novel Sterically Crowded and Conformationally Constrained α-Aminophosphonates with a Near-Neutral pKa as Highly Accurate 31P NMR pH Probes. Application to Subtle pH Gradients Determination in Dictyostelium discoideum Cells
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TN_cdi_doaj_primary_oai_doaj_org_article_bf26cb456a45457b8116b92b0b1ad917
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bf26cb456a45457b8116b92b0b1ad917
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules27144506
