SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mi...
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria
About this item
Full title
Author / Creator
Xue, Yibo , Morris, Jordan L. , Yang, Kangning , Fu, Zheng , Zhu, Xianbing , Johnson, Fraser , Meehan, Brian , Witkowski, Leora , Yasmeen, Amber , Golenar, Tunde , Coatham, Mackenzie , Morin, Geneviève , Monast, Anie , Pilon, Virginie , Fiset, Pierre Olivier , Jung, Sungmi , Gonzalez, Anne V. , Camilleri-Broet, Sophie , Fu, Lili , Postovit, Lynne-Marie , Spicer, Jonathan , Gotlieb, Walter H. , Guiot, Marie-Christine , Rak, Janusz , Park, Morag , Lockwood, William , Foulkes, William D. , Prudent, Julien and Huang, Sidong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Inactivating mutations in
SMARCA4
and concurrent epigenetic silencing of
SMARCA2
characterize subsets of ovarian and lung cancers. Concomitant loss of these key subunits of SWI/SNF chromatin remodeling complexes in both cancers is associated with chemotherapy resistance and poor prognosis. Here, we discover that SMARCA4/2 loss inhibits...
Alternative Titles
Full title
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria
Authors, Artists and Contributors
Author / Creator
Morris, Jordan L.
Yang, Kangning
Fu, Zheng
Zhu, Xianbing
Johnson, Fraser
Meehan, Brian
Witkowski, Leora
Yasmeen, Amber
Golenar, Tunde
Coatham, Mackenzie
Morin, Geneviève
Monast, Anie
Pilon, Virginie
Fiset, Pierre Olivier
Jung, Sungmi
Gonzalez, Anne V.
Camilleri-Broet, Sophie
Fu, Lili
Postovit, Lynne-Marie
Spicer, Jonathan
Gotlieb, Walter H.
Guiot, Marie-Christine
Rak, Janusz
Park, Morag
Lockwood, William
Foulkes, William D.
Prudent, Julien
Huang, Sidong
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_bf575d4233b14e5f997658655553d914
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bf575d4233b14e5f997658655553d914
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25260-9
