FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Aneuploidy, an abnormal chromosome number, has been linked to aging and age-associated diseases, but the underlying molecular mechanisms remain unknown. Here we show, through direct live-cell imaging of young, middle-aged, and old-aged primary human dermal fibroblasts, that aneuploidy increases with aging due to general dysfunction of the mitotic m...
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FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
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TN_cdi_doaj_primary_oai_doaj_org_article_bfcab92a173641ca9b7e59b64b8285c9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bfcab92a173641ca9b7e59b64b8285c9
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2041-1723
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2041-1723
DOI
10.1038/s41467-018-05258-6
