Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The antifungal agent 5-fluorocytosine (5-FC) is used for the treatment of several mycoses, but is unsuitable for monotherapy due to the rapid development of resistance. Here, we show that cryptococci develop resistance to 5-FC at a high frequency when exposed to concentrations several fold above the minimal inhibitory concentration. The genomes of...
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Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
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TN_cdi_doaj_primary_oai_doaj_org_article_c0165229b0b542f78f4b272e586dce76
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c0165229b0b542f78f4b272e586dce76
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-23745-1
