Cryo-EM structure of human glucose transporter GLUT4
Cryo-EM structure of human glucose transporter GLUT4
About this item
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Author / Creator
Yuan, Yafei , Kong, Fang , Xu, Hanwen , Zhu, Angqi , Yan, Nieng and Yan, Chuangye
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
GLUT4 is the primary glucose transporter in adipose and skeletal muscle tissues. Its cellular trafficking is regulated by insulin signaling. Failed or reduced plasma membrane localization of GLUT4 is associated with diabetes. Here, we report the cryo-EM structures of human GLUT4 bound to a small molecule inhibitor cytochalasin B (CCB) at resolution...
Alternative Titles
Full title
Cryo-EM structure of human glucose transporter GLUT4
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TN_cdi_doaj_primary_oai_doaj_org_article_c0376d2dbef2427aa2febc22b9ef7d4a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c0376d2dbef2427aa2febc22b9ef7d4a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-30235-5
