Loureirin B downregulates osteoclast differentiation of bone marrow macrophages by targeting the MAP...
Loureirin B downregulates osteoclast differentiation of bone marrow macrophages by targeting the MAPK signaling pathway
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Author / Creator
Zhang, Jiahao , Mo, Liang , Huang, Haoran , Xu, Jiake , Fan, Yinuo , Li, Weifeng , Wang, Haibin , Zhou, Chi , Fang, Hanjun , He, Wei , Chen, Zhenqiu and Liu, Yuhao
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Excessive absorption of osteoclasts will break the balance between osteoclasts and osteoblasts, leading to bone loss, decreased bone density, and increased bone fragility. We have shown that Loureirin B (LrB) can inhibit osteoclasts. In this study, we demonstrated the targeting-inhibitory mechanism of LrB acting on osteoclast precursor. Using SPR,...
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Full title
Loureirin B downregulates osteoclast differentiation of bone marrow macrophages by targeting the MAPK signaling pathway
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TN_cdi_doaj_primary_oai_doaj_org_article_c03b8b6e2ad64694b27bcac9882f98c0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c03b8b6e2ad64694b27bcac9882f98c0
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-022-18287-5
