Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen
Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen
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Author / Creator
Zhang, Hao , Zhang, Yang , Zhou, Xinyue , Wright, Shaela , Hyle, Judith , Zhao, Lianzhong , An, Jie , Zhao, Xujie , Shao, Ying , Xu, Beisi , Lee, Hyeong-Min , Chen, Taosheng , Zhou, Yang , Chen, Xiang , Lu, Rui and Li, Chunliang
Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
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Publication information
Publisher
England: eLife Science Publications, Ltd
Subjects
More information
Scope and Contents
Contents
Aberrant
HOXA9
expression is a hallmark of most aggressive acute leukemias, notably those with KMT2A (MLL) gene rearrangements.
HOXA9
overexpression not only predicts poor diagnosis and outcome but also plays a critical role in leukemia transformation and maintenance. However, our current understanding of
HOXA9
regulation in leuke...
Alternative Titles
Full title
Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c05bb78898d24b23a12ae92b7e92ebae
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c05bb78898d24b23a12ae92b7e92ebae
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.57858
