Muscle atrophy induced by overexpression of ALAS2 is related to muscle mitochondrial dysfunction
Muscle atrophy induced by overexpression of ALAS2 is related to muscle mitochondrial dysfunction
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Peng, Yahui , Li, Jihong , Luo, Dixian , Zhang, Shuai , Li, Sijia , Wang, Dayong , Wang, Xidi , Zhang, Zhujun , Wang, Xue , Sun, Changhui , Gao, Xu , Hui, Yang and He, Rongzhang
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
ALAS2 (delta-aminolevulinate synthase 2) is one of the two isoenzymes catalyzing the synthesis of delta-aminolevulinic acid (ALA), which is the first precursor of heme synthesis. ALAS2-overexpressing transgenic mice (Tg mice) showed syndrome of porphyria, a series of diseases related to the heme anabolism deficiency. Tg mice showed an obvious decre...
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Full title
Muscle atrophy induced by overexpression of ALAS2 is related to muscle mitochondrial dysfunction
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TN_cdi_doaj_primary_oai_doaj_org_article_c082f52753604722b9351710a0a81412
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c082f52753604722b9351710a0a81412
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ISSN
2044-5040
E-ISSN
2044-5040
DOI
10.1186/s13395-021-00263-8
