High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing...
High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance
About this item
Full title
Author / Creator
Cortés-López, Mariela , Schulz, Laura , Enculescu, Mihaela , Paret, Claudia , Spiekermann, Bea , Quesnel-Vallières, Mathieu , Torres-Diz, Manuel , Unic, Sebastian , Busch, Anke , Orekhova, Anna , Kuban, Monika , Mesitov, Mikhail , Mulorz, Miriam M. , Shraim, Rawan , Kielisch, Fridolin , Faber, Jörg , Barash, Yoseph , Thomas-Tikhonenko, Andrei , Zarnack, Kathi , Legewie, Stefan and König, Julian
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Following CART-19 immunotherapy for B-cell acute lymphoblastic leukaemia (B-ALL), many patients relapse due to loss of the cognate CD19 epitope. Since epitope loss can be caused by aberrant
CD19
exon 2 processing, we herein investigate the regulatory code that controls
CD19
splicing. We combine high-throughput mutagenesis with mathemati...
Alternative Titles
Full title
High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance
Authors, Artists and Contributors
Author / Creator
Schulz, Laura
Enculescu, Mihaela
Paret, Claudia
Spiekermann, Bea
Quesnel-Vallières, Mathieu
Torres-Diz, Manuel
Unic, Sebastian
Busch, Anke
Orekhova, Anna
Kuban, Monika
Mesitov, Mikhail
Mulorz, Miriam M.
Shraim, Rawan
Kielisch, Fridolin
Faber, Jörg
Barash, Yoseph
Thomas-Tikhonenko, Andrei
Zarnack, Kathi
Legewie, Stefan
König, Julian
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c08d347a8dc943b8ab905da6ad76b36d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c08d347a8dc943b8ab905da6ad76b36d
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-31818-y
