PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks
PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks
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London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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DNA polymerase theta (Polθ)-mediated end-joining (TMEJ) repairs DNA double-strand breaks and confers resistance to genotoxic agents. How Polθ is regulated at the molecular level to exert TMEJ remains poorly characterized. We find that Polθ interacts with and is PARylated by PARP1 in a HPF1-independent manner. PARP1 recruits Polθ to the vicinity of...
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Full title
PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks
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TN_cdi_doaj_primary_oai_doaj_org_article_c0a72ae0a24344bb80638065f6025830
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c0a72ae0a24344bb80638065f6025830
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-50158-7
