Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translati...
Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis
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Author / Creator
Chi, Zhexi , Lu, Bo , Liu, Rongjun , Pan, Chen , Meng, Bo , Xing, Xiuzhong , Yuan, Hui , Wu, Xuewei , Chen, Yushan , Ren, Yuxuan , Wu, Wenwei , Miao, Mengmeng , Chen, Junping and Chen, Xiaowei
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Neuropathic pain, a debilitating nerve injury-induced condition, remains a significant clinical challenge. This study evaluates the effect of histone deacetylase 6 (HDAC6) inhibition in a spared nerve injury (SNI) mouse model. Systemic administration of the selective HDAC6 inhibitor ACY-1215 (20 mg/kg/day, 14 days), alleviated SNI-induced pain in m...
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Full title
Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c0c455153b3d4fa0bfdf69b0c3188cd6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c0c455153b3d4fa0bfdf69b0c3188cd6
Other Identifiers
ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-025-03400-y
