Interrelationship between changes in the amyloid β 42/40 ratio and presenilin 1 conformation
Interrelationship between changes in the amyloid β 42/40 ratio and presenilin 1 conformation
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Publisher
England: BioMed Central
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Language
English
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England: BioMed Central
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Contents
The ratio of the longer (i.e., Aβ42/Aβ43) to shorter (i.e. Aβ40) species is a critical factor determining amyloid fibril formation, neurotoxicity and progression of the amyloid pathology in Alzheimer's disease. The relative levels of the different Aβ species are affected by activity and conformation of the γ-secretase complex catalytic component -...
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Full title
Interrelationship between changes in the amyloid β 42/40 ratio and presenilin 1 conformation
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TN_cdi_doaj_primary_oai_doaj_org_article_c0d5c1d466c943fab699bfbb7af77884
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c0d5c1d466c943fab699bfbb7af77884
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ISSN
1076-1551
E-ISSN
1528-3658
DOI
10.2119/molmed.2016.00127
