Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
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Wang, Yuan , Deng, Peng , Liu, Yuting , Wu, Yunshu , Chen, Yaqian , Guo, Yuchen , Zhang, Shiwen , Zheng, Xiaofei , Zhou, Liyan , Liu, Weiqing , Li, Qiwen , Lin, Weimin , Qi, Xingying , Ou, Guomin , Wang, Cunyu and Yuan, Quan
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Age-related osteoporosis is characterized by the deterioration in bone volume and strength, partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) during aging. Alpha-ketoglutarate (αKG) is an essential intermediate in the tricarboxylic acid (TCA) cycle. Studies have revealed that αKG extends the lifespan of worms and ma...
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Full title
Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
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TN_cdi_doaj_primary_oai_doaj_org_article_c0e3afcbf66046cca618c00251e8fdd0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c0e3afcbf66046cca618c00251e8fdd0
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19360-1
